Danazol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. In the treatment of endometriosis, Danocrine alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases. Sirolimus is usually taken once a day. If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.
Further, food also delayed mean time to peak concentration of Danocrine by about 30 minutes. This information should not be used to decide whether or not to take danazol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about danazol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to danazol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using danazol.
Danazol Capsules USP are indicated for the treatment of endometriosis amenable to hormonal management. An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking Danocrine danazol? Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary.
Enyeart JJ, Price WA "Bilateral sensorineural hearing loss from danazol therapy. A case report. Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. Fraser IS "Post danazol amenorrhoea. In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danocrine is usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy.
It should not be given intravenously. Therapy should begin during menstruation. If you are taking danazol for fibrocystic breast disease, you should have a breast exam before starting it. Contact your doctor right away if you experience new or persistent breast pain, tenderness, or lumps while taking danazol. Does Danocrine oral have side effects? Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Other side effects in female patients have included virilization, including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities, due the androgenic activity of danazol the active ingredient contained in Danocrine Discontinuation of danazol at signs of mild virilization may prevent irreversible virilization. Reduction in breast size may occur due to decreased estrogen synthesis. Danazol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using danazol. Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Rosa FW "Virilization of the female fetus with maternal danazol exposure. What should I discuss with my healthcare provider before taking Danocrine danazol? Benzyl alcohol can cross the placenta. See WARNINGS. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Pearson K, Zimmerman HJ "Danazol and liver damage. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Lab tests, including liver function tests and complete blood cell counts, may be performed while you use danazol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. If you miss a dose of danazol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. How should I take Danocrine danazol? Following an initial favorable response prevention of edematous episodes attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg. What other drugs will affect danazol? In the treatment of fibrocystic breast disease, Danazol usually produces partial to complete disappearance of nodularity and complete relief of pain and tenderness. Changes in the menstrual pattern may occur. Sirolimus may increase your risk of developing lymphoma or other forms of cancer. Talk with your doctor about your specific cancer risk. dipyridamole
I'd never taken Danocrine, and I would never recommend it to anyone else. What is sirolimus Rapamune? Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. What happens if I miss a dose Danocrine? This medicine should not be given to a child younger than 13 years old. The oral liquid solution comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Danazol is a man-made form of a steroid. Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Do not use any other liquids to mix this medicine.
An overdose of danazol is not expected to produce life threatening symptoms. However, long term use of high doses can lead to symptoms such as weight gain, increased acne or facial hair, menstrual problems, or breast changes. What should I avoid while taking danazol? Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. When these two medicines are taken together, your body may not process carbamazepine properly. Do not crush, chew, or break a sirolimus tablet. Tell your doctor if you have trouble swallowing the tablet whole. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Genitourinary side effects have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop. Makdisi WJ, Cherian R, Vanveldhuizen PJ, Talley RL, Stark SP, Dixon AY "Fatal peliosis of the liver and spleen in a patient with agnogenic myeloid metaplasia treated with danazol. Hematologic side effects have included thromboembolic and thrombophlebotic events including sagittal sinus thrombosis some resulting in fatal strokes, and increased red cell production. Nakajima T, Mizushima N, Matsuda H, Matsumoto M, Tamakoshi K, Ishii H, Morioka S, Ikeda Y, Terao T, Kanai K "Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Case report. Some medical conditions may interact with danazol. Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. Andriole GL, Brickman C, Lack EE, Sesterhenn IA, Javadpour N, Linehan WM, Frank MM "Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. Danazol has been assigned to pregnancy category X by the FDA. Animal rat studies using danazol at doses 7 to 15 times that of a corresponding human dosage on days 6 to 15 of gestation failed to reveal evidence of teratogenicity or embryotoxicity. Studies in rabbits during days 6 to 18 of gestation at doses 2 to 4 times that of a corresponding human dosage resulted in inhibition of fetal development. There are no controlled data in human pregnancy. Danazol use is considered contraindicated during pregnancy. Danocrine, persistent amenorrhea has occasionally been reported. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns irregular menstrual patterns and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danocrine. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated. price topamax 500 mg walmart
PREGNANCY and BREAST-FEEDING: Do not use danazol if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking danazol. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. The presence of other medical problems may affect the use of this medicine. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine. How should I take danazol? Danazol should not be administered to patients with: 1. Undiagnosed abnormal genital bleeding. 2. Markedly impaired hepatic, renal, or cardiac function. 3. Pregnancy. Before initiating therapy of fibrocystic breast disease with Danocrine, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out. If any of these effects persist or worsen, tell your doctor or promptly. Danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Danazol is an androgen similar to testosterone. For the treatment of endometriosis and fibrocystic breast disease, it works by decreasing the amount of hormones made by the ovaries. These hormones usually make the conditions worse. For the treatment of angioedema, danazol helps to increase the amount of a certain protein in your body's defense system immune system. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. What other drugs will affect danazol Danocrine? Danocrine danazol is a used to treat and fibrocystic breast disease. Danocrine is also used to prevent attacks of in people with an inherited form of this disorder. The brand name Danocrine is discontinued, but versions may be available. Current data are insufficient to assess the carcinogenicity of danazol. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. When the dose of Danocrine is doubled the increase in plasma levels is only about 35% to 40%.
Tell your doctor if your condition does not improve or if it worsens. If your symptoms do not improve or if they become worse, check with your doctor. Absorption: After oral administration of a 400 mg dose to healthy male volunteers, peak plasma concentrations of Danazol are reached between 2 and 8 hours, with a median T max value of 4 hours. Steady state conditions are observed following 6 days of twice daily dosing of Danazol. Current data are insufficient to assess the carcinogenicity of Danazol. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Prolongation of prothrombin time occurs in patients stabilized on warfarin. Therapy with danazol may cause an increase in carbamazepine levels in patients taking both drugs. Danazol can cause insulin resistance when used with antidiabetic drugs. Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. Ask your healthcare professional how you should dispose of any medicine you do not use. Do not use danazol if you are pregnant. It may cause serious harm to a fetus. It is recommended that a pregnancy test be performed before starting danazol. Effective, nonhormonal birth control measures, such as diaphragms and condoms, should be used while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If you become pregnant while taking danazol, stop use and contact your doctor right away. Gray RG "Bilateral carpal tunnel syndrome and arthritis associated with Danazol administration. buy doxycycline without consultation uk
See section for information on carcinogenesis. Metabolic side effects have included significant increases in low density lipoproteins LDL and decreases in high density lipoproteins HDL. Decreased glucose tolerance requiring adjustments in hyperglycemic control has occurred. Tell your doctor or dentist that you take danazol before you receive any medical or dental care, emergency care, or surgery. Duck SC, Katayama KP "Danazol may cause female pseudohermaphroditism. If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation. Using this medicine may cause irregular monthly periods or absence of menstrual period. If your regular monthly period does not begin within 60 to 90 days after you stop taking this medicine, check with your doctor right away. In rare cases, danazol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. All medicines may cause side effects, but many people have no, or minor, side effects. LLC Bridgewater, New Jersey 08807. Revised December 2011. What are the possible side effects of danazol Danocrine? How should I take sirolimus Rapamune? This list is not complete and other drugs may interact with danazol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Moderate. These medicines may cause some risk when taken together. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Use a barrier method of birth control, such as a condom or diaphragm, while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. Schwartz R "Ambiguous genitalia in a term female infant due to exposure to danazol in utero.
What should I discuss with my healthcare provider before taking danazol Danocrine? Generally, the pituitary-suppressive action of Danocrine is reversible. Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with Danocrine is discontinued. Madanes AE, Farber M "Danazol. In the treatment of fibrocystic breast disease, Danocrine usually produces partial to complete disappearance of nodularity and complete relief of pain and tenderness. Changes in the menstrual pattern may occur. Gastrointestinal side effects have included nausea and vomiting. Rare cases of pancreatitis have been reported. Danocrine suppresses the pituitary-ovarian axis. This suppression is probably a combination of depressed hypothalamic-pituitary response to lowered estrogen production, the alteration of sex steroid metabolism, and interaction of danazol with sex hormone receptors. The only other demonstrable hormonal effect is weak androgenic activity. Danocrine depresses the output of both follicle-stimulating hormone FSH and luteinizing hormone LH. Active thrombosis or thromboembolic disease and history of such events. vasotec
Hosea SW, Santaella ML, Brown EJ, Berger M, Katusha K, Frank MM "Long-term therapy of hereditary angioedema with danazol. These hormones usually make the conditions worse. Endometriosis patients - You must take danazol consistently for 3 to 6 months. It may be necessary to take danazol for 9 months. In infrequent patients, symptoms of pain and tenderness may be severe enough to warrant treatment by suppression of ovarian function. Danazol Capsules USP are usually effective in decreasing nodularity, pain, and tenderness. It should be stressed to the patient that this treatment is not innocuous in that it involves considerable alterations of hormone levels and that recurrence of symptoms is very common after cessation of therapy. The following reactions have been reported, a causal relationship to the administration of Danocrine has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. The physician therefore should be alert to this possibility. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Lipitor, Caduet fluvastatin Lescol lovastatin Mevacor, Altoprev, Advicor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Vytorin, Juvisync. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Ask your health care provider any questions you may have about how to use danazol. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Do not start, stop, or change the dosage of any medicine before checking with them first. Should not be used in patients with these conditions. Avoid exposure to sunlight or tanning beds. Sirolimus may increase your risk of skin cancer. Wear protective clothing and use sunscreen SPF 30 or higher when you are outdoors. flucort where to order otc
At first, 800 milligrams mg per day, divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine. The total daily dosage of Danazol capsules for fibrocystic breast disease ranges from 100 mg to 400 mg given in two divided doses depending upon patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danazol capsules. A non-hormonal method of contraception is recommended when Danazol capsules are administered at this dose, since ovulation may not be suppressed. Laboratory monitoring of the hematologic state should be considered. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Danazol may also be used for purposes not listed in this medication guide. If you have any questions about danazol, please talk with your doctor, pharmacist, or other health care provider. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. The information contained in the Truven Health Micromedex products as delivered by Drugs. Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant. Stop taking danazol and tell your doctor right away if you become pregnant during treatment. Capsules of 200 mg orange bottles of 60 NDC 0024-0305-60. Fermand JP, Levy Y, Bouscary D, D'Agay MF, Clot P, Frija J, Brouet JC "Danazol-induced hepatocellular adenoma. Where can I get more information? The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Danazol can diminish the effectiveness of antihypertensive agents.
The dosage requirements for continuous treatment of hereditary angioedema with Danazol capsules should be individualized on the basis of the clinical response of the patient. It is recommended that the patient be started on 200 mg, two or three times a day. After a favorable initial response is obtained in terms of prevention of episodes of edematous attacks, the proper continuing dosage should be determined by decreasing the dosage by 50% or less at intervals of one to three months or longer if frequency of attacks prior to treatment dictates. If an attack occurs, the daily dosage may be increased by up to 200 mg. During the dose adjusting phase, close monitoring of the patient's response is indicated, particularly if the patient has a history of airway involvement. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. What should I discuss with my doctor before taking sirolimus Rapamune? This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using danazol. In female patients, the use of danazol the active ingredient contained in Danocrine may result in virilization including deepening voice, hirsutism, acne, clitomegaly rare and menstrual abnormalities. Discontinuation of medication at signs of mild virilization may prevent irreversible virilization. Sirolimus lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. Bioavailability studies indicate that blood levels do not increase proportionally with increases in the administered dose. Bretza JA, Novey HS, Vaziri ND, Warner AS "Hypertension: a complication of danazol therapy. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Capsules of 100 mg yellow bottles of 100 NDC 0024-0304-06. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. You should not use this medication if you are allergic to danazol, or if you have porphyria, a history of stroke or blood clot, or severe problems with your heart, liver, or kidney. You also should not take danazol if you are pregnant or breast-feeding, if you have breast or uterine cancer, or if you have abnormal vaginal bleeding that has not been checked by a doctor. Middleton C, McCaughan GW, Painter DM, Stephen MS, Beale M, Fraser I "Danazol and hepatic neoplasia: a case report. erbed.info cilostazol
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Use of danazol in pregnancy is contraindicated. Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Therapy with Danazol may cause an increase in carbamazepine levels in patients taking both drugs. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.
Recent evidence suggests a direct inhibitory effect at gonadal sites and a binding of Danocrine to receptors of gonadal steroids at target organs. In addition, Danocrine has been shown to significantly decrease IgG, IgM and IgA levels, as well as phospholipid and IgG isotope autoantibodies in patients with endometriosis and associated elevations of autoantibodies, suggesting this could be another mechanism by which it facilitates regression of the disease. You may take sirolimus with or without food, but take it the same way every time. At first, 200 milligrams mg two or three times a day. Your doctor may adjust your dose as needed and depending upon your condition.
Product Information. Danocrine danazol. Do not stop taking any medications without consulting your healthcare provider. Quagliarello J, Greco MA "Danazol and urogenital sinus formation in pregnancy. Because Danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, polycythemia and hypertension require careful observation. Use with caution in patients with diabetes mellitus. Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse.